Warhammer 40,000: Apocalypse

From the publisher:

Apocalypse allows you to take your battles to a whole new level. No longer will you lead a single detachment of troops into battle. Now you can have hundreds of men and squadron after squadron of vehicles under your command. The greatest heroes of the age battle at the side of your warriors against the hated foe. Huge war machines tower over the battlefield, their super-heavy weapons blowing apart even the most heavily armored tanks and cutting bloody swathes through the enemy ranks. Aircraft scream through the smoke-palled skies, making devastating bombing runs or landing to unleash a horde of bloodthirsty fighters. Orbiting spacecraft fire punishing barrages that pound the enemy into the ground.

The 2007 edition required the use of the Warhammer 40,000 rule book.